This story has spread all over the Asian-American blogosphere. Also, my mother emailed it to me.
NYTimes: Drinkers’ Red Face May Signal Cancer Risk
By NICHOLAS BAKALAR
Published: March 20, 2009
People whose faces turn red when they drink alcohol may be facing more than embarrassment. The flushing may indicate an increased risk for a deadly throat cancer, researchers report.
The flushing response, which may be accompanied by nausea and a rapid heartbeat, is caused mainly by an inherited deficiency in an enzyme called ALDH2, a trait shared by more than a third of people of East Asian ancestry — Japanese, Chinese or Koreans. As little as half a bottle of beer can trigger the reaction.
The deficiency results in problems in metabolizing alcohol, leading to an accumulation in the body of a toxin called acetaldehyde. People with two copies of the gene responsible have such unpleasant reactions that they are unable to consume large amounts of alcohol. This aversion actually protects them against the increased risk for cancer.
But those with only one copy can develop a tolerance to acetaldehyde and become heavy drinkers. [...]
Fascinating. It's a little academic for me now, because I don't drink anymore. I'm not sure if I have one copy or two copies, but the flush always gave me massive problems. My father has it and so do I.
When I was a teenager (and I moved away from home at the age of 15, so don't blame my mother for this!) my circle of friends were heavy drinkers. I'm talking malt liquor and Kool-Aid-mixed-with-Everclear type of heavy drinkers. But drinking didn't come naturally to me. I had to work really, really hard to keep up. Here's a chart of my physiological reaction to different levels of alcohol.
1 beer: I turn bright red. My heart starts beating faster. Everyone asks me how I got the terrible sunburn, and I have to explain, "no, I'm just experiencing an allergic reaction to alcohol that some Asians happen to have". This is very irritating.
2-3 beers: I turn a slightly darker shade of bright red. My heart is pounding, and I begin shivering, no matter what the temperature. I get dizzy and have problems standing up straight.
4 beers: I go sit down on a couch and close my eyes, because I feel so bad. This isn't anything like passing out... I'm basically conscious, I just don't feel like moving.
5-6 beers: If I force myself past the napping stage, I finally get to be
drunk. This is the part of drinking alcohol everyone actually enjoys, I'm guessing. I'm drunk enough to ignore the pounding heartrate and nausea. I'm actually starting to have some fun.
7+ beers: OH NO... IT'S... GODZILLA!!!!!

The angry mutant lizard brain takes control. I begin staggering around with vicious intent, bouncing off the walls, screaming obscene insults at anyone in range, and flailing my arms at them. Luckily, my depth perception is nonexistent at this point, so I don't hit anyone. Then comes the projectile vomiting.
The worst part of all of this is that I've never actually "blacked out". That is, I remember everything I did the next morning.
Anyway, I gave up on heavy drinking by the time I was in my early twenties. When I was in grad school I'd drink at parties, but I'd never go past the napping stage. At a certain point, I'd just say, "Excuse me, I need to rest for a while, I'll be back in about half an hour". Everyone thought it was bizarre and antisocial behavior, but they should have been grateful to me for stopping the Godzilla attack.
And I can't drink wine at all, or champagne. The effects are much worse than with any form of alcohol. After one glass of wine, I feel paralyzed and on the verge of death because my heart starts beating so fast. I've had people actually get visibly angry at me because I refuse a glass of wine in social situations, even after I explain it's not that I want to refuse their hospitality, it's that I
can't. I'll say "I'm allergic to wine" and then they'll deny that it's even possible.
Today, I just don't drink alcohol. Or maybe I'll have one sip of someone else's drink.
Alcoholism makes me really sad. Both my grandparents were alcoholics. My grandfather was a happy drunk. As a child, his drinking never bothered or affected me, and by the time I was an adult he was too ill with cancer to continue drinking. My grandmother, on the other hand, was a mean drunk. I once saw her throw a footstool at my grandfather across the dinner table, just because she was in a particularly nasty mood. She never hit me, but I was always a bit scared of her.
My father also turns bright red. My mother once saw him literally pass out in the soup. He used to be a drinker -- not a particularly heavy one -- but has now quit because of liver issues.
I know that a lot of Asians who have the reaction keep drinking a lot anyway, just like I used to when I was a teenager. Drinking is so much of a social and cultural thing. There's a positive aspect as well as a terribly destructive aspect. All over the world, it's a method for bonding and forming networks. I'm glad I am not a part of it anymore, but being a non-drinker does make me feel cut off and isolated sometimes.